Reproductive and hormonal factors and risk of cognitive impairment among Singapore Chinese women.

ABSTRACT:

Background

Epidemiologic studies suggest that declining estrogen levels in menopause may play an important role in the pathogenesis of dementia and contribute to increased risk of cognitive impairment in women. Most previous studies have been conducted in Western populations to investigate the relationship of the length of reproductive periods and use of hormone-replacement therapy with risk of cognitive function and dementia, but the findings are inconclusive. Relevant evidence among Asian populations is limited.

Objectives

To evaluate the association between reproductive and hormonal factors and the risk of cognitive impairment in Chinese women with natural menopause.

Study design

The Singapore Chinese Health Study is a population-based study that recruited particip

SUBMITTER: Song X 

PROVIDER: S-EPMC7483640 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature