Longer Predialysis ACEi/ARB Utilization Is Associated With Reduced Postdialysis Mortality.

ABSTRACT:

Background

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) improve predialysis outcomes; however, ACEi/ARB are underused in patients transitioning to dialysis. We examined the association of different patterns of predialysis ACEi/ARB use with postdialysis survival and whether potentially modifiable adverse events are associated with lower predialysis ACEi/ARB use.

Methods

This was a historic cohort study of 34,676 US veterans with, and 10,690 without, ACEi/ARB exposure in the 3-year predialysis period who subsequently transitioned to dialysis between 2007 and 2014. Associations of different patterns of predialysis ACEi/ARB use with postdialysis all-cause mortality and with predialysis acute kidney injury and hyperkalemia events were exam

SUBMITTER: Gosmanova EO 

PROVIDER: S-EPMC7483641 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature