Soy food intake associates with changes in the metabolome and reduced blood pressure in a gut microbiota dependent manner.

ABSTRACT:

Background and aims

Consumption of soy foods has been associated with protection against cardiometabolic disease, but the mechanisms are incompletely understood. We hypothesized that habitual soy food consumption associates with gut microbiome composition, metabolite production, and the interaction between diet, microbiota and metabolites.

Methods and results

We analyzed dietary soy intake, plasma and stool metabolites, and gut microbiome data from two independent cross-sectional samples of healthy US individuals (N = 75 lean or overweight, and N = 29 obese). Habitual soy intake associated with several circulating metabolites. There was a significant interaction between soy intake and gut microbiome composition, as defined by gut enterotype, on metabolites in plasma and stoo

SUBMITTER: Shah RD 

PROVIDER: S-EPMC7483644 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature