The mechanism and regulation of vesicular glutamate transport: Coordination with the synaptic vesicle cycle.

ABSTRACT: The transport of classical neurotransmitters into synaptic vesicles generally relies on a H⁺ electrochemical gradient (∆μ_H+). Synaptic vesicle uptake of glutamate depends primarily on the electrical component ∆ψ as the driving force, rather than the chemical component ∆pH. However, the vesicular glutamate transporters (VGLUTs) belong to the solute carrier 17 (SLC17) family, which includes closely related members that function as H⁺ cotransporters. Recent work has also shown that the VGLUTs undergo allosteric regulation by H⁺ and Cl^-, and exhibit an associated Cl^- conductance. These properties appear to coordinate VGLUT activity with the large ionic shifts that accompany the rapid recycling of synaptic vesicles driven by neur

SUBMITTER: Eriksen J 

PROVIDER: S-EPMC7483692 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature