The feasibility of [¹⁸F]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study.

ABSTRACT:

Rationale

Evaluation of the feasibility of [¹⁸F]EF5-PET/CT scan in identifying hypoxic lesions in ovarian tumors in prospective clinical setting.

Methods

Fifteen patients with a suspected malignant ovarian tumor were scanned with [¹⁸F]EF5 and [¹⁸F]FDG-PET/CT preoperatively. The distribution of [¹⁸F]EF5-uptake, total intraabdominal metabolic tumor volume (TMTV), and hypoxic subvolume (HSV) were assessed.

Results

[¹⁸F]EF5-PET/CT suggested hypoxia in 47% (7/15) patients. The median HSV was 87 cm³ (31% of TMTV). The [¹⁸F]EF5-uptake was detected in primary tumors and in four patients also in intra-abdominal metastases. The [¹⁸F]EF5-uptake in cancer tissue was low compared to physiologic

SUBMITTER: Laasik M 

PROVIDER: S-EPMC7483702 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature