CYP2S1 is a synthetic lethal target in BRAF^V600E-driven thyroid cancers.

ABSTRACT: BRAF^V600E is the most common genetic alteration and has become a major therapeutic target in thyroid cancers; however, intrinsic feedback mechanism limited clinical use of BRAF^V600E specific inhibitors. Synthetic lethal is a kind of interaction between two genes, where only simultaneously perturbing both of the genes can lead to lethality. Here, we identified CYP2S1 as a synthetic lethal partner of BRAF^V600E in thyroid cancers. First, we found that CYP2S1 was highly expressed in papillary thyroid cancers (PTCs) compared to normal thyroid tissues, particularly in conventional PTCs (CPTCs) and tall-cell PTCs (TCPTCs), and its expression was positively associated with BRAF^V600E mutation. CYP2S1 knockdown selectively inhibited cell proliferation, mig

SUBMITTER: Li Y 

PROVIDER: S-EPMC7483764 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature