Genome-wide non-HLA donor-recipient genetic differences influence renal allograft survival via early allograft fibrosis.

ABSTRACT: Donor-recipient (D-R) differences at human leukocyte antigen (HLA) loci are currently incorporated into organ sharing, allocation and immunosuppression decisions. However, while acute rejection episodes have substantially diminished, progressive histologic damage occurs in allografts and improved long-term survival remains an unrealized goal among kidney recipients. Here we tested the hypothesis that non-HLA dependent, genome-wide D-R genetic differences could contribute to unchecked alloimmunity with histologic and functional consequences, culminating in long-term allograft failure. Genome-wide single nucleotide polymorphism (SNP) array data, excluding the HLA region, was utilized from 385 transplants to study the role of D-R differences upon serial histology and allograft survival. ADMIX

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7483801 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature