The Effect of Timing of Adjuvant Therapy on Survival After Esophagectomy.

ABSTRACT:

Background

Adjuvant chemotherapy (AC) after esophagectomy improves survival in esophageal cancer when induction therapy is not given; however, the optimal timing for initiation of AC is poorly characterized. We aimed to determine the impact of timing of AC on survival after esophagectomy.

Methods

The National Cancer Database was queried for patients with pT1-4aNxM0 esophageal cancer receiving AC with or without radiation from 2004 to 2015. The median and interquartile range of time to AC were determined. Patients were stratified by initiation of AC into 4 cohorts based on quartiles. Kaplan-Meier curves were generated and factors associated with survival were identified by Cox proportional hazards modeling. A separate analysis was performed with time to AC as a continuous var

SUBMITTER: Rhodin KE 

PROVIDER: S-EPMC7483824 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature