Assessment of reproductive and developmental effects of graphene oxide on Japanese medaka (Oryzias latipes).

ABSTRACT: Due to its unique properties, graphene oxide (GO) has potential for biomedical and electronic applications, however environmental contamination including aquatic ecosystem is inevitable. Moreover, potential risks of GO in aquatic life are inadequately explored. Present study was designed to evaluate GO as an endocrine disrupting chemical (EDC) using the model Japanese medaka (Oryzias latipes). GO was injected intraperitoneally (25-200 μg/g) once to breeding pairs and continued pair breeding an additional 21 days. Eggs laid were analyzed for fecundity and the fertilized eggs were evaluated for developmental abnormalities including hatching. Histopathological evaluation of gonads, liver, and kidneys was made 21 days post-injection. LD₅₀ was found to be sex-dependent. Fecundity ten

SUBMITTER: Dasmahapatra AK 

PROVIDER: S-EPMC7483842 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature