Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus.

ABSTRACT: The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens¹. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is released from hepatocytes without lysis in small vesicles that resemble exosomes^2,3. These quasi-enveloped virions are infectious and are the only form of virus that can be detected in the blood during acute infection². By contrast, non-enveloped naked virions are shed in faeces and stripped of membranes by bile salts during passage through the bile ducts to the gut⁴. How these two distinct types of infectious hepatoviruses enter cells to initiate infection is unclear. Here, we describe a genome-w

SUBMITTER: Das A 

PROVIDER: S-EPMC7483933 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature