Long-term survival of 1338 MM patients treated with tandem autologous vs. autologous-allogeneic transplantation.

ABSTRACT: Contrary to tandem autologous transplant (auto-auto), autologous followed by reduced intensity conditioning allogenic transplantation (auto-allo) offers graft-versus-myeloma (GVM) effect but with higher toxicity. Trials comparing these two strategies relied on availability of HLA-matched sibling donors for arm allocation (biological randomization) and yielded conflicting results. A pooled analysis of multiple trials with extended follow up provides an opportunity to compare these strategies. We obtained individual patient data from participants of four trials comparing auto-auto vs. auto-allo after induction therapy. There were 899 patients in auto-auto and 439 in auto-allo. Median follow up of survivors was 118.5 months. Median overall survival (OS) was 78.0 months in auto-auto and 98.3 m

SUBMITTER: Costa LJ 

PROVIDER: S-EPMC7483973 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature