Bariatric surgery to achieve transplant in end-stage organ disease patients: A systematic review and meta-analysis.
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ABSTRACT: Background
As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing.Methods
We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing.Results
Among 82 heart failure patients, 40.2% lost sufficient weight for listing, 29.3% were transplanted, and 8.5% had sufficient improvement with weight loss they no longer required transplantation. Among 28 end-stage lung disease patients, 28.6% lost sufficient weight for listing, 7.1% were transplanted, and 14.3% had sufficient improvement following weight loss they no longer required transplant. Among 41 cirrhosis patients, 58.5% lost sufficient weight for listing, 41.5% were transplanted, and 21.9% had sufficient improvement following weight loss they no longer required transplant. Among 288 end-stage/chronic kidney disease patients, 50.3% lost sufficient weight for listing and 29.5% were transplanted.Conclusions
Small sample size and publication bias are limitations; however, bariatric surgery may benefit select end-stage organ disease patients with obesity that precludes transplant candidacy.
SUBMITTER: Orandi BJ
PROVIDER: S-EPMC7484004 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Bariatric surgery to achieve transplant in end-stage organ disease patients: A systematic review and meta-analysis.
Orandi Babak J BJ Purvis Joshua W JW Cannon Robert M RM Smith A Blair AB Lewis Cora E CE Terrault Norah A NA Locke Jayme E JE
American journal of surgery 20200613 3
<h4>Background</h4>As obesity prevalence grows, more end-stage organ disease patients will be precluded from transplant. Numerous reports suggest bariatric surgery in end-stage organ disease may help patients achieve weight loss sufficient for transplant listing.<h4>Methods</h4>We performed a systematic review/meta-analysis of studies of bariatric surgery to achieve solid organ transplant listing.<h4>Results</h4>Among 82 heart failure patients, 40.2% lost sufficient weight for listing, 29.3% wer ...[more]
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