Systematic review and meta-analysis of studies assessing the relationship between statin use and risk of ovarian cancer.

ABSTRACT:

Purpose

The link between lipid-stabilizing medications and epithelial ovarian carcinogenesis is incompletely understood. Statins may reduce ovarian cancer risk, but results are inconclusive.

Methods

We conducted a systematic review and meta-analysis of studies reporting associations between statin use and ovarian cancer risk in PubMed. Summary risk ratios (RRs) and confidence intervals (CIs) were calculated. Subgroup analyses by cancer histotype, statin class (lipo- or hydrophilic) and duration of statin use were conducted. Use of individual statins in populations was assessed to determine population-specific differences in statin types.

Results

Nine studies with 435,237 total women were included (1 randomized controlled trial (RCT); 4 prospective; 4 case-control). St

SUBMITTER: Irvin S 

PROVIDER: S-EPMC7484024 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature