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Natural-abundance 17O NMR spectroscopy of magnetically aligned lipid nanodiscs.


ABSTRACT: Natural-abundance 17O NMR experiments are used to investigate the hydrated water in magnetically aligned synthetic polymer based lipid-nanodiscs. Residual quadrupole couplings (RQCs) measured from the observed five 17O (central and satellite) transitions, and molecular dynamics simulations, are used to probe the ordering of water molecules across the lipid bilayer.

SUBMITTER: Ravula T 

PROVIDER: S-EPMC7484029 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Natural-abundance <sup>17</sup>O NMR spectroscopy of magnetically aligned lipid nanodiscs.

Ravula Thirupathi T   Sahoo Bikash R BR   Dai Xiaofeng X   Ramamoorthy Ayyalusamy A  

Chemical communications (Cambridge, England) 20200801 69


Natural-abundance 17O NMR experiments are used to investigate the hydrated water in magnetically aligned synthetic polymer based lipid-nanodiscs. Residual quadrupole couplings (RQCs) measured from the observed five 17O (central and satellite) transitions, and molecular dynamics simulations, are used to probe the ordering of water molecules across the lipid bilayer. ...[more]

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