How hydrogel inclusions modulate the local mechanical response in early and fully formed post-infarcted myocardium.

ABSTRACT: Expansion of myocardium after myocardial infarction (MI) has long been identified as the primary mechanism that drives adverse left ventricular (LV) remodeling towards heart failure and death. Direct injection of hydrogels into the myocardium to mechanically constrain the infarct has demonstrated promise in limiting its remodeling and expansion. Despite early successes, there remain open questions in the determination of optimal hydrogel therapies, key application characteristics for which include injected polymer volume, stiffness, and spatial placement. Addressing these questions is complicated by the substantial variations in infarct type and extent, as well as limited understanding of the underlying mechanisms. Herein, we present an investigation on how hydrogel inclusions affect the e

SUBMITTER: Li DS 

PROVIDER: S-EPMC7484038 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature