MTORC1 and mTORC2 expression in inner retinal neurons and glial cells.

ABSTRACT: The retina is one of the most metabolically active tissues, yet the processes that control retinal metabolism remains poorly understood. The mTOR complex (mTORC) that drives protein and lipid biogenesis and autophagy has been studied extensively in regards to retinal development and responses to optic nerve injury but the processes that regulate homeostasis in the adult retina have not been determined. We previously demonstrated that normal adult retina has high rates of protein synthesis compared to skeletal muscle, associated with high levels of mechanistic target of rapamycin (mTOR), a kinase that forms multi-subunit complexes that sense and integrate diverse environmental cues to control cell and tissue physiology. This study was undertaken to: 1) quantify expression of mTOR complex 1

SUBMITTER: Losiewicz MK 

PROVIDER: S-EPMC7484061 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature