Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling.

ABSTRACT: The musculoskeletal system is a striking example of how cell identity and position is coordinated across multiple tissues to ensure function. However, it is unclear upon tissue loss, such as complete loss of cells of a central musculoskeletal connecting tendon, whether neighboring tissues harbor progenitors capable of mediating regeneration. Here, using a zebrafish model, we genetically ablate all embryonic tendon cells and find complete regeneration of tendon structure and pattern. We identify two regenerative progenitor populations, sox10⁺ perichondrial cells surrounding cartilage and nkx2.5⁺ cells surrounding muscle. Surprisingly, laser ablation of sox10⁺ cells, but not nkx2.5⁺ cells, increases tendon progenitor number in the perichondrium, su

SUBMITTER: Niu X 

PROVIDER: S-EPMC7484193 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature