Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.

ABSTRACT:

Background

The Ca²⁺/calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the β isoform of the calcineurin catalytic A-subunit (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in the same cells. It is unclear how the pleiotropic second messenger Ca²⁺ drives excitation-contraction coupling while not stimulating hypertrophy by calcineurin in the normal heart. Elucidation of the mechanisms conferring this selectivity in calcineurin signaling should reveal new strategies for targeting the phosphatase in disease.

Methods

Primary adult rat ventricular myocytes were studied for morphology and intracellular signaling. New Fö

SUBMITTER: Li X 

PROVIDER: S-EPMC7484230 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature