Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials.

ABSTRACT:

Background

Testosterone treatment increases erythrocytes in men, but its effects on leukocyte and platelet counts are unknown and could affect its safety.

Objective

To determine whether testosterone affects circulating leukocytes and platelets in men.

Methods

Secondary analyses of two randomized testosterone trials were performed: the 5α-reductase (5aR) and OPTIMEN trials. In 5aR trial, 102 healthy men, 21-50 years (mean age 38), received a long-acting GnRH agonist, and 50, 125, 300, or 600 mg/week testosterone enanthate (TE) plus placebo or 2.5 mg_/ day dutasteride for 20 weeks. In OPTIMEN, 78 functionally limited men, ≥65 years (mean age 72) with protein intake ≤ 0.83 g kg^-1  day^-1 , were randomized to controlled diets with 0.8 g kg

SUBMITTER: Gagliano-Juca T 

PROVIDER: S-EPMC7484244 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature