Chemically functionalized conical PET nanopore for protein detection at the single-molecule level.

ABSTRACT: Proteins are essential for all living organisms, and perform a wide variety of functions in the cell and human body, including structural, mechanical, biochemical, and signaling. Since proteins can serve as valuable biomarkers for health status and diseases states, and enable personalized medicine, sensitive and rapid detection of proteins is of paramount importance. Herein, we report a chemically functionalized conical shaped poly-(ethylene terephthalate) nanopore (PET nanopore) as a stochastic sensing element for detection of proteins at the single-molecule level. We demonstrate that the PET nanopore sensor is not only sensitive and selective, but also can differentiate proteins rapidly, offering the potential for label-free protein detection and characterization. Our developed PET nanop

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7484250 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature