Systemic iron overload exacerbates osteoarthritis in the strain 13 guinea pig.

ABSTRACT:

Objective

Iron is emerging as a key player in aging-associated diseases due to its propensity for driving free radical formation. Studies examining the role of iron in the pathogenesis of primary osteoarthritis (OA) are limited. Our objective was to establish a direct relationship between excess iron and OA by administering iron dextran to a guinea pig strain with decreased propensity for developing this disease.

Design

Twenty, 12-week-old Strain 13 guinea pigs received either iron dextran or dextran control intraperitoneally once weekly for 4 weeks; termination occurred at 16 weeks of age. Iron levels were determined systemically (serum and liver) and within diarthrodial joints [femoral head articular cartilage and infrapatellar fat pads (IFPs) of knee joints]. One knee was

SUBMITTER: Burton LH 

PROVIDER: S-EPMC7484276 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature