Fractures in children and adolescents living with perinatally acquired HIV.

ABSTRACT:

Background

Across numerous settings, bone mineral density for age and sex is lower in children/adolescents living with perinatally-acquired HIV (PHIV) compared to uninfected peers. We assessed incidences of any fracture/any long bone fracture, and osteoporosis prevalence in PHIV and HIV-exposed uninfected (PHEU) participants in the Pediatric HIV/AIDS Cohort Study (PHACS).

Methodology

Lifetime history of fracture events from birth up to age 20 years was obtained by chart review and/or interview, including age at fracture, mechanism, and bone(s) fractured. Poisson regression models were fit comparing fracture incidence by HIV status adjusted for age, sex, and race, with effect modification by age (<6, ≥6 yr).

Results

PHIV (N = 412) were older (median 17.5 vs 16.7 yr) an

SUBMITTER: Jacobson DL 

PROVIDER: S-EPMC7484335 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature