A kinetic analysis of mouse rod and cone photoreceptor responses.

ABSTRACT:

Key points

Most vertebrate eyes have rods for dim-light vision and cones for brighter light and higher temporal sensitivity. Rods evolved from cone-like precursors through expression of different transduction genes or the same genes at different expression levels, but we do not know which molecular differences were most important. We approached this problem by analysing rod and cone responses with the same model but with different values for model parameters. We showed that, in addition to outer-segment volume, the most important differences between rods and cones are: (1) decreased transduction gain, reflecting smaller amplification in the G-protein cascade; (2) a faster rate of turnover of the second messenger cGMP in darkness; and (3) an accelerated rate of decay of the effector

SUBMITTER: Reingruber J 

PROVIDER: S-EPMC7484371 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature