Alcohol Use Disorders Are Associated With a Unique Impact on Airway Epithelial Cell Gene Expression.

ABSTRACT:

Background

Alcohol use disorders (AUDs) and cigarette smoking both increase risk for the development of community-acquired pneumonia (CAP), likely through adverse effects on proximal airway mucociliary clearance and pathogen recognition. Smoking-related alterations on airway gene expression are well described, but little is known about the impact of AUDs. We measured gene expression in human airway epithelial cells (AECs), hypothesizing that AUDs would be associated with novel differences in gene expression that could alter risk for CAP.

Methods

Bronchoscopy with airway brushings was performed in participants with AUDs and controls to obtain AECs. An AUD Identification Test was used to define AUD. RNA was extracted from AECs, and mRNA expression data were collected on an Agi

SUBMITTER: Bailey KL 

PROVIDER: S-EPMC7484391 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature