Early CD4+ T cell reconstitution as predictor of outcomes after allogeneic hematopoietic cell transplantation.

ABSTRACT:

Background

An association between early CD4+ T cell immune reconstitution (CD4+ IR) and survival after T-replete allogeneic hematopoietic cell transplantation (HCT) has been previously reported. Here we report validation of this relationship in a separate cohort that included recipients of ex vivo T-cell-depleted (TCD) HCT. We studied the relationship between CD4+ IR and clinical outcomes.

Methods

A retrospective analysis of children/young adults receiving their first allogeneic HCT for any indication between January 2008 and December 2017 was performed. We related early CD4+ IR (defined as achieving >50 CD4+ T cells/µL on two consecutive measures within 100 days of HCT) to overall survival (OS), relapse, non-relapse mortality (NRM), event-free survival (EFS) and acute graft

SUBMITTER: van Roessel I 

PROVIDER: S-EPMC7484404 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature