Network structures and temporal stability of self- and informant-rated affective symptoms in Alzheimer's disease.

ABSTRACT:

Background

Affective symptoms in Alzheimer's disease (AD) can be rated with both informant- and self-ratings. Information from these two modalities may not converge. We estimated network structures of affective symptoms in AD with both rating modalities and assessed the longitudinal stability of the networks.

Methods

Network analyses combining self-rated and informant-rated affective symptoms were conducted in 3198 individuals with AD at two time points (mean follow-up 387 days), drawn from the NACC database. Self-rated symptoms were assessed by Geriatric Depression Scale, and informant-rated symptoms included depression, apathy and anxiety questions from Neuropsychiatric Inventory Questionnaire.

Results

Informant-rated symptoms were mainly connected to symptoms expre

SUBMITTER: Saari TT 

PROVIDER: S-EPMC7484410 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature