Genomic Binding Patterns of Forkhead Box Protein O1 Reveal Its Unique Role in Cardiac Hypertrophy.

ABSTRACT:

Background

Cardiac hypertrophic growth is mediated by robust changes in gene expression and changes that underlie the increase in cardiomyocyte size. The former is regulated by RNA polymerase II (pol II) de novo recruitment or loss; the latter involves incremental increases in the transcriptional elongation activity of pol II that is preassembled at the transcription start site. The differential regulation of these distinct processes by transcription factors remains unknown. Forkhead box protein O1 (FoxO1) is an insulin-sensitive transcription factor that is also regulated by hypertrophic stimuli in the heart. However, the scope of its gene regulation remains unexplored.

Methods

To address this, we performed FoxO1 chromatin immunoprecipitation-deep sequencing in mouse hearts

SUBMITTER: Pfleger J 

PROVIDER: S-EPMC7484435 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature