Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.

ABSTRACT: Deglycosylated, live-attenuated SIV vaccines elicited protective immune responses against heterologous SIVsmE543-3, which differs from the vaccine strain SIVmac239 to levels similar to those across HIV-1 clades. Two thirds of the vaccinees contained the chronic SIVsmE543-3 infection (controllers), whereas one third did not (noncontrollers). In this study, we investigated immune correlates of heterologous challenge control in rhesus macaques of Burmese origin. Because depletion of CD8⁺ cells in the controllers by administration of anti-CD8α Ab abrogated the control of viral replication, CD8⁺ cells were required for the protective immune response. However, classical SIV-specific CD8⁺ T cells did not account for the protective immune response in all controller

SUBMITTER: Watanabe S 

PROVIDER: S-EPMC7484436 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature