Analysis of pneumonitis and esophageal injury after stereotactic body radiation therapy for ultra-central lung tumors.

ABSTRACT:

Objectives

SBRT has been associated with serious toxicity in ultra-central lung tumors, but little is known about the incidence and dosimetric correlates of pulmonary and esophageal complications in this setting.

Materials and methods

We retrospectively reviewed SBRT patients whose lung tumor abutted proximal airways, or whose planning target volume overlapped esophagus. All patients received 5-15 fractions of high-dose, image-guided radiation. The primary endpoint was SBRT-related toxicity, with local control and survival as secondary endpoints.

Results

We included 88 patients. Nineteen patients (22 %) experienced grade ≥3 (G3+) toxicity, including 6 cases of G3+ radiation pneumonitis and 4 cases of G3+ esophageal injury. Two patients developed trachea-esophageal fis

SUBMITTER: Wang C 

PROVIDER: S-EPMC7484437 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature