Reduced hippocampal and amygdala volume as a mechanism underlying stress sensitization to depression following childhood trauma.

ABSTRACT:

Background

Stressful life events are more likely to trigger depression among individuals exposed to childhood adversity. However, the mechanisms underlying this stress sensitization remain largely unknown. Any such mechanism must be altered by childhood adversity and interact with recent stressful life events, magnifying their association with depression.

Aim

This study investigated whether reduced hippocampal and amygdala volume are potential mechanisms underlying stress sensitization following childhood violence exposure.

Method

A sample of 149 youth (aged 8-17 years), with (N = 75) and without (N = 74) exposure to physical abuse, sexual abuse, or domestic violence participated. Participants completed a structural MRI scan and assessments of depression. Approximatel

SUBMITTER: Weissman DG 

PROVIDER: S-EPMC7484449 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature