Ontology highlight
ABSTRACT:
SUBMITTER: DiStefano TJ
PROVIDER: S-EPMC7484452 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
DiStefano Tyler J TJ Shmukler Jennifer O JO Danias George G Di Pauli von Treuheim Theodor T Hom Warren W WW Goldberg David A DA Laudier Damien M DM Nasser Philip R PR Hecht Andrew C AC Nicoll Steven B SB Iatridis James C JC
Biomaterials 20200812
Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poor adhesion to wetted tissue surfaces or low failure strength resulting in considerable risk of implant herniation upon spinal loading. Here, we developed a two-part repair strategy ...[more]