A systematic review of minor phytocannabinoids with promising neuroprotective potential.

ABSTRACT: Embase and PubMed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, apart from cannabidiol and Δ⁹ -tetrahydrocannabinol, including Δ⁹ -tetrahydrocannabinolic acid, Δ⁹ -tetrahydrocannabivarin, cannabidiolic acid, cannabidivarin, cannabichromene, cannabichromenic acid, cannabichromevarin, cannabigerol, cannabigerolic acid, cannabigerivarin, cannabigerovarinic acid, cannabichromevarinic acid, cannabidivarinic acid, and cannabinol. Out of 2,341 studies, 31 articles met inclusion criteria. Cannabigerol (range 5 to 20 mg·kg^-1 ) and cannabidivarin (range 0.2 to 400 mg·kg^-1 ) displayed efficacy in models of Huntington's disease and epilepsy. Cannabichromene (10-75 mg·kg^-1 ), Δ<

SUBMITTER: Stone NL 

PROVIDER: S-EPMC7484504 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature