Hypersensitivity to amphetamine's psychomotor and reinforcing effects in serotonin transporter knockout rats: Glutamate in the nucleus accumbens.

ABSTRACT:

Background and purpose

Amphetamine (AMPH) use disorder is a serious health concern, but, surprisingly, little is known about the vulnerability to the moderate and compulsive use of this psychostimulant and its underlying mechanisms. Previous research showed that inherited serotonin transporter (SERT) down-regulation increases the motor response to cocaine, as well as moderate (as measured during daily 1-h self-administration sessions) and compulsive (as measured during daily 6-h self-administration sessions) intake of this psychostimulant. Here, we sought to investigate whether these findings generalize to AMPH and the underlying mechanisms in the nucleus accumbens.

Experimental approach

In serotonin transporter knockout (SERT^-/- ) and wild-type control (SERT

SUBMITTER: Caffino L 

PROVIDER: S-EPMC7484509 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature