Plasma metabolomic profiles in liver cancer patients following stereotactic body radiotherapy.

ABSTRACT:

Background

Stereotactic body radiotherapy (SBRT) is an effective treatment for hepatocellular carcinoma (HCC). This study sought to identify differentially expressed plasma metabolites in HCC patients at baseline and early during SBRT, and to explore if changes in these metabolites early during SBRT may serve as biomarkers for radiation-induced liver injury and/or tumour response.

Methods

Forty-seven HCC patients were treated with SBRT on previously published prospective trials. Plasma samples were collected at baseline and after one to two fractions of SBRT, and analysed by GC/MS and LC/MS for untargeted and targeted metabolomics profiling, respectively.

Findings

Sixty-nine metabolites at baseline and 62 metabolites after one to two fractions of SBRT were differentia

SUBMITTER: Ng SSW 

PROVIDER: S-EPMC7484529 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature