Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity.

ABSTRACT: Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the release of small molecules (auto-inducers) by bacteria that accumulate in the environment depending on bacterial cell density. These molecules not only are sensed by the microbial community but also interact with host cells and contribute to gut homeostasis. It therefore appears entirely appropriate to highlight the role of these molecules on the immune system in dysbiosis-associated inflammatory conditions where the bacterial populations are imbalanced. Here, we intent to focus on one of the most studied QS molecule family, namely, the type I auto-inducers represented by N-acyl-homoserine lactones (AHL). First described in path

SUBMITTER: Coquant G 

PROVIDER: S-EPMC7484616 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature