Serum transferrin predicts end-stage Renal Disease in Type 2 Diabetes Mellitus patients.

ABSTRACT: Background: To investigate the relationship between serum iron status and renal outcome in patients with type 2 diabetes mellitus (T2DM). Methods: Chinese patients (n=111) with T2DM and biopsy-proven diabetic nephropathy (DN) were surveyed in a longitudinal, retrospective study. Serum iron, total iron-binding capacity, ferritin, and transferrin were measured at the time of renal biopsy. Iron deposition and transferrin staining were performed with renal biopsy specimens of DN patients and potential kidney donors. End-stage renal disease (ESRD) was the end-point. ESRD was defined as an estimated glomerular filtration rate <15 mL/min/1.73 m² or the need for chronic renal replacement therapy. Cox proportional hazard models were used to estimate the hazard ratios (HRs)

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7484672 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature