Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Exploratory Analysis of Insult Burden.

ABSTRACT: Pressure reactivity index (PRx) and brain tissue oxygen (PbtO₂) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO₂ in adult moderate/severe TBI. Using the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high resolution intensive care unit (ICU) sub-study cohort, we evaluated those patients with archived high-frequency digital intraparenchymal intracranial pressure (ICP) and PbtO₂ monitoring data of, a minimum of 6 h in duration, and the presence of a 6 month Glasgow Outcome Scale -Extended (GOSE) score. Digital physiological signals were processed for ICP, PbtO₂, and PRx, with the % time above/below defined thresholds determined.

SUBMITTER: Zeiler FA 

PROVIDER: S-EPMC7484893 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature