Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.

ABSTRACT:

Background and aims

Cardiovascular disease (CVD) is the leading cause of death in chronic kidney disease (CKD) patients, however, the underlying mechanisms that link CKD and CVD are not fully understood and limited treatment options exist in this high-risk population. microRNAs (miRNA) are critical regulators of gene expression for many biological processes in atherosclerosis, including endothelial dysfunction and inflammation. We hypothesized that renal injury-induced endothelial miRNAs promote atherosclerosis. Here, we demonstrate that dual inhibition of endothelial miRNAs inhibits atherosclerosis in the setting of renal injury.

Methods

Aortic endothelial miRNAs were analyzed in apolipoprotein E-deficient (Apoe^-/-) mice with renal damage (5/6 nephrectomy, 5/6Nx)

SUBMITTER: Wiese CB 

PROVIDER: S-EPMC7484899 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature