Ethyl acetate extract of Ceiba pentandra (L.) Gaertn. reduces methotrexate-induced renal damage in rats via antioxidant, anti-inflammatory, and antiapoptotic actions.

ABSTRACT: Methotrexate (MTX) is a chemotherapeutic agent and an immunosuppressant used to treat cancer and autoimmune diseases. However, its use is limited by its multi-organ toxicity, including nephrotoxicity, which is related to MTX-driven oxidative stress. Silencing oxidative stressors is therefore an important strategy in minimizing MTX adverse effects.Medicinal plants rich in phenolic compounds are probable candidates to overcome these oxidants. Herein, C. pentandra ethyl acetate extract showed powerful in vitro radical-scavenging potential (IC₅₀ = 0.0716) comparable to those of the standard natural (ascorbic acid, IC₅₀ = 0.045) and synthetic (BHA, IC₅₀ = 0.056) antioxidants. The effect of C. pentandra ethyl acetate extract aga

SUBMITTER: Abouelela ME 

PROVIDER: S-EPMC7484958 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature