Phage Display Derived Monoclonal Antibodies: From Bench to Bedside.

ABSTRACT: Monoclonal antibodies (mAbs) have become one of the most important classes of biopharmaceutical products, and they continue to dominate the universe of biopharmaceutical markets in terms of approval and sales. They are the most profitable single product class, where they represent six of the top ten selling drugs. At the beginning of the 1990s, an in vitro antibody selection technology known as antibody phage display was developed by John McCafferty and Sir. Gregory Winter that enabled the discovery of human antibodies for diverse applications, particularly antibody-based drugs. They created combinatorial antibody libraries on filamentous phage to be utilized for generating antigen specific antibodies in a matter of weeks. Since then, more than 70 phage-derived antibodies entered cl

SUBMITTER: Alfaleh MA 

PROVIDER: S-EPMC7485114 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature