ZMAT2 in Humans and Other Primates: A Highly Conserved and Understudied Gene.

ABSTRACT: Recent advances in genetics present unique opportunities for enhancing our understanding of human physiology and disease predisposition through detailed analysis of gene structure, expression, and population variation via examination of data in publicly accessible genome and gene expression repositories. Yet, the vast majority of human genes remain understudied. Here, we show the scope of these genomic and genetic resources by evaluating ZMAT2, a member of a 5-gene family that through May 2020 had been the focus of only 4 peer-reviewed scientific publications. Using analysis of information extracted from public databases, we show that human ZMAT2 is a 6-exon gene and find that it exhibits minimal genetic variation in human populations and in disease states, including cancer.

SUBMITTER: Baral K 

PROVIDER: S-EPMC7485168 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature