Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design.

ABSTRACT:

Introduction

Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited genetic disease. It carries an extremely high cardiovascular risk associated with significantly elevated low-density lipoprotein (LDL) cholesterol. The diagnostic rate of this disease in some European nations is quite high, due to the presence of multiple prospective registries. On the other hand, few data-and in particular multicentre data-exist regarding this issue among Japanese subjects. Therefore, this study intends to assemble a multicentre registry that aims to comprehensively assess cardiovascular risk among Japanese FH patients while taking into account their genetic backgrounds.

Methods and analysis

The Hokuriku-plus FH registry is a prospective, observational, multicentre cohort st

SUBMITTER: Tada H 

PROVIDER: S-EPMC7485236 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature