Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the comparative efficacy of traditional non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclo-oxygenase-2 inhibitors in patients with acute gout.

Design

Systematic review and meta-analysis.

Data sources

Medline, Web of Science, China National Knowledge Infrastructure and Wanfang Data published as of 4 April 2020.

Methods

We performed meta-analysis of randomised controlled trials (RCTs) of traditional non-selective NSAIDs versus cyclo-oxygenase-2 inhibitors and RCTs of various cyclo-oxygenase-2 inhibitors in patients with acute gout. The main outcome measures were mean change in pain Visual Analogue Scale (VAS) score and 5-point Likert scale score on days 2-8.

Results

Twenty-four trials involving five drugs were evaluated.

SUBMITTER: Li M 

PROVIDER: S-EPMC7485255 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature