Neutrophil gelatinase-associated lipocalin combined with delta serum creatinine provides early risk stratification for adverse outcomes after cardiac surgery: a prospective observational study.

ABSTRACT:

Objectives

Novel biomarkers of renal injury appear inconsistent in identifying a creatinine-based diagnosis of acute kidney injury. To be clinically useful, novel acute kidney injury biomarkers should identify patients at increased risk for adverse outcomes that are a consequence of acute kidney injury earlier and with greater utility than conventional creatinine-based metrics. We sought to determine the prognostic utility of both urinary neutrophil gelatinase-associated lipocalin and varying creatinine-based metrics of renal injury at multiple time points associated with cardiac surgery.

Design

Prospective observational study.

Setting

Academic medical center.

Patients

Six hundred three adults undergoing cardiac surgery.

Interventions

Nil.

Measurement

SUBMITTER: McIlroy DR 

PROVIDER: S-EPMC7485262 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature