Effects of Six Sequential Charged Particle Beams on Behavioral and Cognitive Performance in B6D2F1 Female and Male Mice.

ABSTRACT: The radiation environment astronauts are exposed to in deep space includes galactic cosmic radiation (GCR) with different proportions of all naturally occurring ions. To assist NASA with assessment of risk to the brain following exposure to a mixture of ions broadly representative of the GCR, we assessed the behavioral and cognitive performance of female and male C57BL/6J × DBA2/J F1 (B6D2F1) mice two months following rapidly delivered, sequential 6 beam irradiation with protons (1 GeV, LET = 0.24 keV, 50%), ⁴He ions (250 MeV/n, LET = 1.6 keV/μm, 20%), ¹⁶O ions (250 MeV/n, LET = 25 keV/μm 7.5%), ²⁸Si ions (263 MeV/n, LET = 78 keV/μm, 7.5%), ⁴⁸Ti ions (1 GeV/n, LET = 107 keV/μm, 7.5%), and ⁵⁶Fe ions (1 GeV/n, LET = 151 keV/μm, 7.5%) at

SUBMITTER: Raber J 

PROVIDER: S-EPMC7485338 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature