Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.

ABSTRACT:

Background

Male lower urinary tract symptoms (LUTS) occur in more than half of men above 50 years of age. LUTS were traditionally attributed to benign prostatic hyperplasia (BPH) and therefore the clinical terminology often uses LUTS and BPH interchangeably. More recently, LUTS were also linked to fibrogenic and inflammatory processes. We tested whether osteopontin (OPN), a proinflammatory and profibrotic molecule, is increased in symptomatic BPH. We also tested whether prostate epithelial and stromal cells secrete OPN in response to proinflammatory stimuli and identified downstream targets of OPN in prostate stromal cells.

Methods

Immunohistochemistry was performed on prostate sections obtained from the transition zone of patients who underwent surgery (Holmium laser enucle

SUBMITTER: Popovics P 

PROVIDER: S-EPMC7485377 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature