Altered Static and Dynamic Spontaneous Neural Activity in Drug-Naive and Drug-Receiving Benign Childhood Epilepsy With Centrotemporal Spikes.

ABSTRACT: The present study aims to investigate intrinsic abnormalities of brain and the effect of antiepileptic treatment on brain activity in Benign childhood epilepsy with centrotemporal spikes (BECTS). Twenty-six drug-naïve patients (DNP) and 22 drug-receiving patients (DRP) with BECTS were collected in this study. Static amplitude of low frequency fluctuation (sALFF) and dynamic ALFF (dALFF) were applied to resting-state fMRI data. Functional connectivity (FC) analysis was further performed for affected regions identified by static and dynamic analysis. One-way analysis of variance and post hoc statistical analyses were performed for between-group differences. Abnormal sALFF and dALFF values were correlated with clinical features of patients. Compared with healthy controls (HC), DNP grou

SUBMITTER: Jiang S 

PROVIDER: S-EPMC7485420 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature