Usefulness of the cytokines expression of Th1/Th2/Th17 and urinary CD80 excretion in adult-onset minimal change disease.

ABSTRACT:

Background

Minimal change disease (MCD) is a common form of nephrotic syndrome in adults. However, the molecular mechanism underlying the pathogenesis of MCD remains incompletely understood. In this study, we aimed to investigate the role of the cytokines expression of Th1/Th2/Th17 and urinary CD80 excretion in adult-onset MCD patients.

Methods

The lymphocyte subsets, 34 cytokine levels of Th1/Th2/Th17, serum and urine concentrations of CD80, and expression of CD80 in glomeruli were analyzed in 28 cases (15 males and 13 females; average age: 34.1 years, age range: 18-56 years), including 10 patients with MCD in relapse, nine patients with MCD in remission and nine healthy controls.

Results

There was no significant difference of CD3⁺CD4⁺ cells pro

SUBMITTER: Chen P 

PROVIDER: S-EPMC7485503 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature