Cantharidin Induces Apoptosis and Promotes Differentiation of AML Cells Through Nuclear Receptor Nur77-Mediated Signaling Pathway.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by uncontrolled proliferation and accumulation of myeloblasts in the bone marrow (BM), blood, and other organs. The nuclear receptors Nur77 is a common feature in leukemic blasts and has emerged as a key therapeutic target for AML. Cantharidin (CTD), a main medicinal component of Mylabris (blister beetle), exerts an anticancer effect in multiple types of cancer cells.

Purpose

This study aims to characterize the anti-AML activity of CTD in vitro and in vivo and explore the potential role of Nur77 signaling pathway.

Study design/methods

The inhibition of CTD on cell viability was performed in different AML cells, and then the inhibition of CTD on proliferation and colony fo

SUBMITTER: Yu Z 

PROVIDER: S-EPMC7485522 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature