Improved survival after lung transplantation for adults requiring preoperative invasive mechanical ventilation: A national cohort study.

ABSTRACT:

Objective

Early survival after lung transplantation has improved in the last decade. Mechanically ventilated recipients are known to be at greater risk for early post-transplant mortality. We hypothesized that post-transplant survival in mechanically ventilated recipients has improved over time.

Methods

Using a national registry, we compared hazard of death at 30 days, 4 and 14 months, 3 and 5 years, and overall for adults on mechanical ventilation who underwent lung or heart-lung transplantation from May 4, 2011, to April 4, 2018 (modern group) with those undergoing transplantation from May 4, 2005, to May 3, 2011 (early group). We quantified the impact of mechanical ventilation on survival using population-attributable fractions. We also compared mechanically ventilated re

SUBMITTER: Hamilton BCS 

PROVIDER: S-EPMC7485564 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature